What is the influence of the old man's childbearing on the embryo quality?

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The Influence of Male's Old Childbearing on Embryo Quality

The elderly childbearing of a man means that a man still chooses to have children at a later age. Compared with the elderly childbearing of women, the elderly childbearing of men has less scientific research and public attention. However, recent studies have shown that a man's old age may have an impact on embryo quality. In the following, we will elaborate on the influence of the old childbearing of the man on the embryo quality from four aspects: genetic mutation, chromosome abnormality, gene stability and reproductive health.

Genetic mutation

The sperm quality of men decreases with age, which may lead to an increase in genetic mutations. Research shows that old men will increase the probability of DNA damage and mutation in sperm, thus affecting the quality of embryos. Genetic mutations in sperm may cause chromosome abnormalities, embryo termination and increased risk of congenital diseases during embryonic development.

In addition, older men are also associated with an increased risk of genetic disease in newborns. For example, children whose fathers are older than 35 have a higher risk of autism and schizophrenia. Therefore, the increase of genetic mutation may have an adverse impact on the quality of embryos.

Chromosomal abnormality

Older male fertility is associated with an increased risk of chromosomal abnormalities. Chromosome abnormalities in sperm may be caused by factors such as sperm division and DNA damage. Embryos with abnormal chromosomes may have problems such as abortion, malformation and embryo death during development.

In recent years, a study found that children whose fathers are over 40 years old have a significantly increased risk of Down syndrome. Down syndrome is a common chromosomal disorder caused by the presence of extra chromosome 21 in embryos during fertilization. It is estimated that when the father is over 45 years old, the risk of Down syndrome will increase to more than 15 times.

Gene stability

The aging of male fertility may affect the genetic stability of their sperm. Older fathers suffer from high frequency microsatellite instability (HD). This genetic disease is related to the amplification and reduction of microsatellite regions in sperm DNA, which may lead to chromosome instability and mutation during embryonic development.

In addition to HD, older men are also associated with an increased risk of other genetic diseases, such as muscular dystrophy. These diseases may be caused by abnormal sperm DNA, thus affecting the quality of embryos.

reproductive health

The advanced age of men may affect their reproductive health, and thus affect the quality of embryos. With the growth of age, the quality and quantity of male sperm will decline. The abnormal rate of sperm morphology and the rate of DNA fragments increased, which may have adverse effects on the development and quality of embryos.

In addition, the study also found that older men are associated with lower fertility and higher risk of infertility. Infertility may lead to low quality sperm entering the egg, affecting the quality and development of the embryo.

Summary

The old childbearing of the man has a certain impact on the embryo quality. Genetic mutation, chromosome abnormality, gene stability and reproductive health are the main aspects of the impact of male aging fertility on embryo quality. The aging of male fertility may lead to the decline of sperm quality, the increase of genetic mutations and chromosome abnormalities, as well as the decrease of sperm gene stability and fertility. Therefore, for elderly male family planning couples, they should fully understand these risks, consult professional doctors, and take appropriate measures to improve embryo quality and reduce related risks.