Can men's fertility at an advanced age be prolonged?

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The age limit of male fertility and the extension of time

With the increase of social pressure and the priority of career development, more and more men begin to postpone the time of starting a family and having children. However, the growth of age has a significant impact on male fertility. Next, we will discuss the age limit of male fertility and the extension of time in detail from four aspects: the quality of spermatogenic cells, sperm quality, sexual function and gene stability.

Quality of spermatogenic cells

The main key to male fertility lies in the quality and quantity of sperm. In the process of spermatogenesis, the quality of spermatogenic cells has a direct impact on the quality of the final sperm. However, with age, the quality of male spermatogenic cells will gradually decline. A study shows that the quality of spermatogenic cells of men over 40 years old is 10-15% lower than that of men under 30 years old. This means that aging will lead to the damage of male spermatogenic cells, thus affecting the quality and quantity of sperm.

In addition, the increase of age may also lead to the increase of chromosome abnormalities. The study found that men over 40 years old are three times more likely to suffer from chromosomal abnormalities than men under 30 years old. Chromosome abnormalities will directly affect the normal development of embryos and increase the risk of embryo malformation and abortion.

Sperm quality

The influence of age on male sperm quality cannot be ignored. The study found that the older the men, the higher the proportion of abnormal sperm activity and morphology, and the concentration and number of sperm will also be reduced. This means that the growth of age will reduce the quality of male sperm, thus affecting the success rate of pregnancy.

In addition, aging may also increase the risk of DNA damage in semen. Research shows that the proportion of DNA fragments in semen of men over 40 years old is higher than that of men under 30 years old. These DNA damages may affect the normal development and health of embryos.

Sexual function

With the growth of age, male sexual function will also change to a certain extent. Research shows that men over the age of 50 are twice as likely to suffer from erectile dysfunction as men under the age of 40. Sexual dysfunction may lead to erectile difficulties, ejaculation problems and reduced frequency of sexual behavior, which may affect fertility.

In addition, some other health problems related to sexual dysfunction, such as cardiovascular disease and diabetes, are also important reasons for male fertility decline. The risk of these health problems increases with age, further limiting men's fertility at an advanced age.

Gene stability

The increase of age may also lead to the weakening of male gene stability. As the number of cell divisions increases, the DNA repair mechanism may be defective, thus increasing the risk of chromosomal abnormalities and mutations. These gene variations may have adverse effects on the development and health of the next generation.

To sum up, male fertility at an advanced age has been restricted in many ways. With the increase of age, the quality of male spermatogenic cells and sperm declined, sexual function changed, and gene stability weakened. These factors will undoubtedly have a negative impact on male fertility. Therefore, men should try to avoid being too late when considering childbearing, so as to improve the chance of success in childbearing.