Is there any relationship between the aging childbearing age of men and the quality of embryo health?

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The Influence of Male Old Childbearing Age on the Quality of Embryo Health

With the development of society and the improvement of people's living standards, more and more men choose to give birth at an advanced age. However, is the aging of male fertility related to the quality of embryo health? This article will elaborate on reproductive capacity, genetic variation, DNA damage and sperm quality.

1、 Reproductive capacity

The male reproductive capacity will gradually decline with age. Research shows that after the age of 30, the proportion of men with normal sperm density, motility and morphology begins to decline. This is directly related to the relationship between the aging childbearing age of men and the quality of embryo health.

First of all, the number of germ cells in elderly men has decreased, thus reducing the chance of embryo formation. Secondly, the decrease of sperm activity will affect the successful combination of sperm and egg, and then affect the fertilization process and embryonic development. Therefore, the increase in the age of older men will increase the duration of pregnancy, thereby affecting the quality of embryonic health.

In addition, the aging of men is also related to the decline of sperm quality, which will be further discussed below.

2、 Genetic variation

The increase in the age at which men are old enough to have children is also related to the risk of genetic variation. Research has found that male sperm will mutate during DNA replication, and these mutations may be passed on to the next generation. The risk of mutation increases with age.

Genetic variation may lead to abnormal gene and chromosome structure in embryos, thus affecting the quality of embryo health. Some common genetic diseases, such as Down's syndrome and chromosomal abnormalities, are related to the father's old childbearing age.

Therefore, the increase in the age of male aging will increase the risk of genetic variation of embryos, and thus affect the health quality of embryos.

3、 DNA damage

The risk of DNA damage in men's sperm increases with age. The study found that there was a certain correlation between the aging childbearing age of men and sperm DNA damage.

Sperm DNA damage may lead to abnormal development of fertilized eggs, embryo stop development or embryo implantation failure. This phenomenon may be related to the decline of DNA repair ability of men in advanced age.

Therefore, the increase in the age at which men are old enough to have children will increase the risk of DNA damage in embryos, thus affecting the health quality of embryos.

4、 Sperm quality

The increase of the male reproductive age is related to the decrease of sperm quality. Studies have shown that after the age of 40, the proportion of men with normal sperm morphology is significantly reduced, the antioxidant capacity of sperm is reduced, and the integrity of sperm DNA is reduced.

The decline of sperm quality will directly affect the quality of embryo health. Abnormal sperm is easy to cause abnormal development of fertilized egg or embryo. Spermatozoa with abnormal DNA may lead to embryo abnormalities or chromosome abnormalities.

Therefore, the increase in the age of male aging will lead to the decline of sperm quality, thus affecting the health quality of embryos.

Summary

There is a close relationship between the aging childbearing age of men and the quality of embryo health. The decline of reproductive capacity, the increased risk of genetic variation, the increase of DNA damage, and the decline of sperm quality are all important factors that affect the quality of embryo health in older men.

Therefore, when the childbearing age of older men increases, enough attention should be paid to carry out fertility planning as soon as possible to reduce the adverse effects on the health and quality of embryos.