Effect of premature ovarian failure on the quality of test tube infants
Premature ovarian failure (POF) refers to the condition that women's ovarian function declines or stops before the age of 45, which will have an important impact on the quality of IVF. The following will elaborate how premature ovarian failure affects the quality of IVF from four aspects: ovarian hormone secretion, egg quality, gamete DNA damage and pregnancy complications.
Ovarian hormone secretion
Premature ovarian failure (POF) can lead to the reduction or imbalance of hormone secretion in the ovary, especially follicle stimulating hormone (FSH) and estrogen. This will have a significant impact on the quality of IVF. If the follicles are not fully developed or the follicles have different maturity levels, the quality of the removed eggs will be affected.
In addition, due to the decrease of estrogen level, the implantation of embryos by endometrium may also be affected, leading to the decrease of IVF implantation rate. Therefore, patients with premature ovarian failure need additional hormone support during IVF to improve the quality of eggs and promote embryo implantation.
Egg mass
Premature ovarian failure will lead to a decline in egg quality. Due to the inhibition of follicular development, the maturity and quality of oocytes will be affected. The number of eggs in the ovary decreases, and the quality of the remaining eggs may also decrease.
The main problem caused by the decline of egg cell quality is the increase of chromosome abnormalities, including chromosome number abnormalities (such as trisomy syndrome) and structural abnormalities. These chromosomal abnormalities will affect embryonic development and pregnancy results, leading to a decline in the quality of IVF and an increase in abnormal pregnancy rates.
Gamete DNA damage
Premature ovarian failure may expose eggs to free radicals and oxidative stress. This will lead to the damage of egg nuclear DNA and the decline of repair ability, further affecting the quality of IVF.
The damage of gamete DNA may lead to delayed embryonic development, chromosome aberration and pregnancy failure. These injuries may also affect the implantation of embryos and the normal development of embryos after pregnancy.
Pregnancy complications
When patients with premature ovarian failure are treated with IVF, they usually need to be treated with higher doses of hormone because of poor ovarian function. This will increase the risk of pregnancy complications for patients.
For example, patients with premature ovarian failure may have pregnancy induced hypertension syndrome, placental insufficiency, premature delivery and low birth weight infants during pregnancy. These complications will affect the quality of IVF and the health of mothers and infants.
Summary
Premature ovarian failure has many effects on the quality of IVF. The decrease of ovarian hormone secretion will affect the maturation of eggs and the implantation of embryos into endometrium. The decrease of egg quality will increase the occurrence of chromosomal abnormalities. The damage of gamete DNA will affect the development and implantation ability of embryos, while pregnancy complications will affect the pregnancy results and the health of mothers and infants. Therefore, the patients with premature ovarian failure need to carefully select the appropriate treatment scheme in the IVF treatment, and accept the comprehensive guidance and monitoring of doctors to improve the success rate and quality of IVF.
