Causes of IVF abortion
IVF abortion refers to the situation that the embryo cannot be successfully embedded into the uterine wall at the early stage of pregnancy, and eventually leads to the loss of the embryo during the assisted reproductive technology. There are many reasons for IVF abortion, including the following aspects:
Genetic factor
Genetic abnormality is one of the common causes of IVF abortion. During the development of human embryo, it is necessary to correctly transmit genetic information and carry out cell division. If there are genetic abnormalities such as defective chromosome structure, abnormal chromosome number or gene mutation, it may cause the embryo to stop developing before embedding into the uterine wall, thus causing abortion.
In addition, some couples with genetic diseases choose to use IVF technology for assisted reproduction. However, due to gene mutation or genetic defect of genetic disease itself, the quality of embryo development may be affected, thus increasing the risk of abortion.
In order to reduce the risk of abortion caused by genetic factors, doctors usually conduct gene screening before embryo transfer to select healthy embryos for transfer, thus increasing the probability of successful pregnancy.
Uterine factor
Uterine factors are also one of the common reasons for IVF abortion. The endometrium needs to have conditions suitable for embryo implantation at the early stage of pregnancy, including adequate thickness and good blood supply. If the endometrium is too thin or has abnormal changes, it may affect the implantation of the embryo, leading to abortion.
Abnormal uterine morphology may also increase the risk of IVF abortion. For example, endometriosis, uterine mediastinum, hysteromyoma and other uterine structural abnormalities may adversely affect embryo implantation and development. In addition, the history of uterine surgery (such as cesarean section) may also affect the blood supply and elasticity of the endometrium, thus increasing the risk of abortion.
In view of the risk of abortion caused by uterine factors, doctors will correct uterine abnormalities through various operations or auxiliary treatment to improve the chances of embryo implantation and pregnancy success.
Immune factor
Immune factor is another important reason for IVF abortion. Under normal circumstances, the immune system will respond to foreign objects to protect the body from infection and damage. However, some immune abnormalities may cause the immune system to attack the embryo, making it unable to develop normally.
Immune factors include autoimmune diseases, anti embryonic antibodies and immune responses. Autoimmune diseases, such as systemic lupus erythematosus and antiphospholipid antibody syndrome, can cause the immune system to attack the endometrium and embryos, thus increasing the risk of abortion. Anti embryonic antibody is an antibody formed in the blood of the body. It will attack the cells on the surface of the embryo and affect the implantation and development of the embryo.
In view of the risk of abortion caused by immune factors, doctors will carry out relevant immune function tests on patients and treat them accordingly according to the test results to reduce the damage of the immune system to embryos.
Lifestyle and environmental factors
Lifestyle and environmental factors also play an important role in IVF abortion. For example, bad living habits such as smoking, alcohol abuse and drug abuse will have a negative impact on embryo implantation and development, increasing the risk of abortion.
Environmental pollutants may also have adverse effects on IVF pregnancy. Some environmental factors such as chemicals, heavy metals and radiation are considered as teratogens, which will increase the risk of abnormal embryonic development and abortion.
Therefore, in order to reduce the impact of lifestyle and environmental factors on IVF pregnancy, couples preparing for pregnancy should actively improve their living habits, avoid exposure to harmful substances and maintain a good living environment.
summary
IVF abortion is a complex problem. Common reasons include genetic factors, uterine factors, immune factors, lifestyle and environmental factors. Understanding these reasons is very important for couples who are preparing to become pregnant, and appropriate methods can be found to reduce the risk of abortion. With the guidance of doctors and the help of assistive technology, the pregnancy success rate of IVF can be improved and couples can realize their reproductive dreams.
