Common causes of IVF abortion
IVF is a way to help infertile couples realize their reproductive dreams by implanting embryos into their mother's uterus after in vitro fertilization and embryo culture through assisted reproductive technology. However, IVF abortion is a frustrating result. Abortion refers to the failure of an embryo or fetus to survive in the early stages of pregnancy and to be discharged from the uterus naturally. The abortion rate of IVF is slightly higher than that of natural pregnancy. The common reasons for abortion include the following aspects:
Embryonic factor
Embryo factor is one of the main reasons for IVF abortion. Possible causes include chromosome abnormalities, gene mutations and some genetic diseases of the embryo. Chromosome abnormality is one of the main causes of abortion, and the new chromosome abnormality usually comes from the inheritance of mother or father. If the chromosome is abnormal, the embryo will encounter serious problems during development, leading to abortion.
In addition, gene mutation may also lead to abortion of IVF. Some gene mutations can lead to embryonic dysplasia, or even failure to develop into a fetus, leading to abortion. Some genetic diseases can cause serious problems during embryonic development, increasing the risk of miscarriage. Therefore, in the process of IVF, abortion can be reduced through embryonic gene testing.
Uterine factor
Uterine factors are also an important reason for IVF abortion. Factors such as weak endometrium, uterine cavity malformation or hysteromyoma will increase the risk of abortion. Weak endometrium means that the endometrium is too thin, which will affect the implantation and fixation of embryos in the endometrium. Intrauterine malformations, including intrauterine septum and cervical horizontal malformations, will affect embryo implantation and increase the risk of embryo retention in the uterine cavity. Uterine myoma is a common uterine tumor. Although most uterine myomas have little impact on the abortion risk of IVF, if the myoma is large or in a poor position, it may cause abortion. Therefore, proper uterine examination is very important before IVF.
Immune factor
Immune factors may also lead to IVF abortion. When the human immune system has an immune response to the embryo, it will cause the embryo to fail to develop normally in the uterus, and eventually lead to abortion. Patients with habitual abortion may have some problems with immune factors, such as pelvic inflammation, leukocyte antibodies and thyroid autoantibodies. Localization and targeted treatment of these immune factors are effective means to reduce abortion.
Hormonal factor
Hormone factors are also common causes of IVF abortion. Progesterone is the main hormone to maintain pregnancy. If it is insufficient, the embryo will not develop normally, thus causing abortion. In the process of IVF, in order to supplement progesterone, IVF patients are often given supplementary treatment to reduce the risk of abortion. In addition, thyroid dysfunction may also cause IVF abortion, malnutrition, endocrine disorders and other factors will also increase the risk of abortion.
Summary
IVF abortion is a frustrating result, but not all abortions are inevitable. Embryonic factors, uterine factors, immune factors and hormone factors are the common causes of IVF abortion. Understanding these reasons can help couples and doctors make corresponding adjustments and interventions, thus reducing the risk of miscarriage. In the process of IVF, appropriate genetic, uterine and immune tests, as well as regular monitoring of hormone levels, are important measures to reduce the abortion rate.
