Main factors of IVF abortion
IVF abortion refers to that in the process of assisted reproductive technology (ART), the embryo cannot develop normally in the uterus, which eventually leads to the termination of pregnancy. Abortion is the grief that has destroyed the dreams of many IVF babies. The following will elaborate on the main factors of IVF abortion from four aspects: embryo quality, endocrine factors, adenomyosis and infection factors.
Embryo quality
Embryo quality is one of the important factors affecting IVF abortion. In the process of IVF transfer, the quality of embryos is directly related to the success rate of pregnancy. If the embryo is in a low quality state, its ability to carry out normal pregnancy is poor, and it is prone to miscarriage. The main influencing factors of embryo quality include chromosome abnormality of embryo, stagnation of embryo development and quality problems in embryo.
Embryonic chromosome abnormality is an important cause of IVF abortion. Due to the existence of chromosome abnormalities in the embryo, the embryo cannot develop normally, which is easy to lead to pregnancy failure and abortion. In addition, the stagnation of embryonic development is also one of the key factors leading to abortion. After transplantation, the embryo failed to continue to develop normally and stagnated at an earlier stage of development, resulting in abortion.
In addition, intraembryonic quality is also one of the factors affecting IVF abortion. In the process of embryo development, if the adhesion between embryonic cells is weak, it is easy to lead to embryo implantation failure, which will lead to abortion.
Endocrine factor
Endocrine factors are another important reason for IVF abortion. Endocrine balance is very important for normal pregnancy. If the endocrine function is abnormal, it will directly affect the intrauterine environment, resulting in difficulty in IVF implantation and abortion.
Luteal insufficiency is a common endocrine factor, which usually refers to insufficient luteinization or short duration of luteal function. Inadequate luteinization will lead to endometrial dysplasia, making the embryo unable to implant normally. At the same time, too short duration of luteal function will lead to changes in the uterine environment, increase the risk of embryo loss, and then lead to abortion.
In addition, the imbalance of androgen and estrogen levels is also an important reason for endocrine factors leading to IVF abortion. High androgen level or low estrogen level will interfere with the development and stability of endometrium, thus affecting the normal implantation of embryos.
Adenomyosis
Adenomyosis is also an important factor leading to IVF abortion. Adenomyosis is a common gynecological disease with irregular smooth muscle nodules in the endometrium. These nodules will have an impact on the shape and structure of the uterine cavity, leading to IVF implantation problems and abortion.
Adenomyosis will thin the endometrium, weaken the ability of embryo implantation, and lead to the failure of IVF pregnancy. In addition, adenomyosis may also lead to uterine peristalsis disorder, affect embryonic development and pregnancy process, and increase the risk of abortion.
Infectious factors
Infection is also an important reason for IVF abortion. Infection can directly affect the health of endometrium, leading to difficulties in embryo implantation and abortion. Common infection factors include bacterial infection and viral infection.
Bacterial infection, especially vaginal infection, is one of the common causes of IVF abortion. Vaginal infection will increase endometritis and affect the normal implantation and development of embryos.
Virus infection can also lead to IVF abortion. For example, cytomegalovirus infection can cause embryonic development disorders, leading to abortion. Infection with gynecological viruses also increases the risk of IVF abortion.
Summary
The main factors of IVF abortion include embryo quality, endocrine factors, adenomyosis and infection factors. Embryo quality directly affects the normal development of embryos and pregnancy results. Abnormal endocrine function will interfere with the stability of endometrium and embryo implantation. Adenomyosis will affect the shape and structure of the endometrium, thus increasing the risk of miscarriage. Infection factors can lead to endometritis and embryonic development disorders, leading to abortion. In the process of IVF, we should pay attention to the influence of these factors and take corresponding preventive and therapeutic measures to improve the success rate of IVF and reduce the risk of abortion.
