Types of down-regulation drugs for IVF
In vitro fertilization (IVF) is a method of combining sperm and eggs in the laboratory, and then implanting the fertilized eggs into the mother's uterus to develop into embryos, which ultimately leads to a successful pregnancy. In the process of IVF, in order to increase the success rate of pregnancy, doctors often give patients some drugs to reduce ovarian function and ovulation, so as to better control the development of eggs and fertilization process. The following will introduce the available drugs for IVF downregulation from four aspects.
Estrogen antagonist
Estrogen antagonists are commonly used in the process of IVF, and there are three common types: aspirin, ergotamine and lenalidomide.
First, aspirin is an antiplatelet drug, which can reduce endometrial blood flow by inhibiting the activation and aggregation of platelets, thus reducing the development of ovarian follicles. Secondly, ergotamine is a drug that can inhibit the secretion of estrogen, and plays a down-regulation role mainly by blocking the release of hypothalamic pituitary follicle stimulating hormone. Finally, lenalidomide is also a drug that inhibits the secretion of estrogen, and reduces the development of follicles in the ovary by inhibiting the secretion of follicle stimulating hormone in the pituitary gland.
Gonadotropin
Gonadotropin is a class of drugs commonly used in clinic for lowering the regulation of IVF, which mainly includes follicle stimulating hormone and luteinizing hormone.
First, follicle stimulating hormone is a kind of drug that can promote the growth and development of follicles. The commonly used drugs are human chorionic gonadotropin (hMG) and simple follicle stimulating hormone (rFSH). Secondly, luteinizing hormone is used to promote the growth and development of corpus luteum. Common drugs include human chorionic gonadotropin and hyaluronic acid luteinizing hormone.
Progesterone and progesterone
Progesterone and progesterone are drugs used to help maintain and stabilize endometrium and increase the success rate of implantation.
First, progesterone is mainly used to maintain and stabilize the thickness of endometrium and ensure the success of embryo implantation. Common progesterone drugs include group progesterone, progesterone soft capsules, etc. Secondly, progesterone is also an important hormone used to help embryo implantation. It is often used in combination with other drugs to improve the success rate of IVF.
Other auxiliary drugs
In the process of IVF, other adjuvant drugs can also be used to help control ovarian function and increase the success rate of pregnancy.
First, antioxidant drugs are often used to help alleviate oxidative stress and damage that may be caused by ovarian activity. Common antioxidant drugs include vitamin E, vitamin C, etc. Secondly, anti-inflammatory drugs are also one of the commonly used adjuvant drugs, which can reduce the inflammatory reaction of ovarian tissue and improve the success rate of IVF.
Summary
There are many kinds of drugs for IVF, including estrogen antagonists, gonadotropins, progesterone and progesterone, as well as other auxiliary drugs. These drugs can effectively control the ovarian function and ovulation process, thus improving the success rate of IVF. In practical clinical application, doctors will choose appropriate drug combinations according to the specific conditions of patients to achieve the best therapeutic effect.
