Causes of failure of IVF transplantation
IVF is an assisted reproductive technology, which helps couples who cannot conceive naturally realize their reproductive aspirations by transplanting the fertilized eggs into the mother's uterus. However, sometimes IVF transplants fail, leading to the disappointment of couples' expectations. The following is a detailed analysis of the reasons for the failure of IVF transplantation from different perspectives.
1. Embryo quality problems
Embryo quality is one of the most important factors in IVF. If the embryo has abnormal development or gene defect, it will affect the implantation ability of the embryo. Embryo quality is affected by many factors, such as gamete quality, fertilization ability, etc. Before IVF transplantation, embryo quality assessment in Hangzhou Union Medical College Hospital and other professional institutions will help to screen high-quality embryos and improve the success rate of transplantation.
In addition, the preservation and freezing process of embryos will also affect their quality. In the process of embryo freezing and thawing, if the operation is improper, the embryo will be damaged and the transfer will fail.
Finally, there are embryo selection involving gene mutation. If healthy embryos without gene defects are not successfully screened, the risk of transfer failure will be relatively high.
2. Uterine cavity problems
The success of IVF transplantation is also closely related to the condition of uterine cavity. Abnormal uterine cavity may cause difficulty in implantation, including endometrial abnormalities, endometrial polyps, uterine fibroids, etc. For example, problems such as insufficient endometrial thickness and ischemia will reduce the success rate of embryo implantation.
In addition, the abnormal shape of the uterine cavity, such as the diaphragm or uterine septum, will also affect the implantation of embryos. Specific uterine morphological problems need to be corrected through surgery to improve the success rate of transplantation.
3. Immune system problems
The immune system plays an important role in IVF transplantation. If the female immune system is abnormal, it may carry out an immune attack on the embryo, resulting in difficulty in embryo implantation. On the other hand, if the male has abnormal immune system, it may affect sperm quality and reduce embryo quality.
The abnormality of immune system involves many factors, such as autoimmune diseases, antisperm antibodies, etc. Immune related tests can be carried out before IVF transplantation. If abnormalities are found, appropriate treatment measures can be selected to improve the immune system function and the success rate of transplantation.
4. Life habits and mentality
Life habits and mentality will also affect the results of IVF transplantation. Bad living habits, such as drinking, smoking, and lack of sleep, may have a negative impact on the success rate of IVF transplantation.
In addition, excessive psychological pressure may also interfere with IVF transplantation. Negative emotions such as anxiety and tension will release a large number of stress hormones, which will inhibit ovarian function and affect embryo quality. Therefore, it is very important to maintain a good attitude in the process of IVF transplantation.
summary
There are many reasons for the failure of IVF transplantation, including embryo quality problems, uterine cavity problems, immune system problems, life habits and psychological problems. To improve the success rate of IVF transplantation, it is necessary to comprehensively assess the patient's physical condition and embryo quality, and pay attention to personal living habits and mental health. Only through comprehensive treatment and improvement of the physical and psychological status of prospective parents can the success rate of IVF transplantation be improved.
