Injection of thin face lasts longer than Dysport

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Not long ago, the editor wrote an article about the third injection face slimming brand approved by China, Dysport Injection Face slimming, which is about to be launched. Dysport, a popular science popular "Play in the Morning" with Dysport's products rising rapidly, got up at night and left messages on the background, which are mostly more features of Dysport that doctors want to know.

After reading and studying, Xiao Bian has mixed feelings. Today, the editor will select some internal explanations for in-depth thinking. We don't blow or black. From the perspective of doctors' clinical application, we should sort out which views are beneficial to our clinical practice and which views can be laughed off.

Remember, Due to the exploration and respect for injection face thinning and injection technology of different brands, any point of view has become a point of view.

Next, let's enter today's science popularization time. Someone took a screenshot to show the point to the editor: Does injection of thin face last longer than Dysport?

After checking, the screenshot came from American BOTOX vs. British Dysport. How to choose an article? The small editor smiled at the screenshot. I wonder if you have seen the details. The small editor uses a red line to mark:

Did you see it? This is a summary of the maintenance time of brow lines in 2009. In other words, this is not a Botox and Dysport comparative test, but two different studies.

a key! The two different research sample sizes, sample populations, test methods and evaluation methods are different. How to get them? "Injection of thin face lasts longer than Dysport"?

After searching Pubmed, we can find that there are many clinical literatures about the comparison between different brands of injection face slimming and placebo in different times, different control groups, different doses, different researchers and different evaluation methods. This is why we say that head to point clinical trials are needed to compare brand characteristics (if you are a doctor, you will immediately understand what I am talking about).

This misleading is like Zhang San eating a piece of sweet potato for two hours today; Li Si ate a steamed bun for an hour tomorrow; Therefore, it is concluded that sweet potato is better than steamed bread.

So what do these two studies say respectively? Let's go back to the research itself and see if they have any brand comparisons.

2012

Richard Glogau's research

Richard Glogau This study summarizes the data of similar design in the phase III clinical trial of face thinning injection, mainly determining the maintenance time of the treatment of brow wrinkles by face thinning injection. Among 621 patients in the injection face reduction treatment group (20U), 84. On the 30th day, there were 2% patients. The median duration of these patients was 120 days at the time of large contraction and 131 days at rest. The conclusion of this study is that more than 50% of patients with wrinkles can be treated with 20U injection for 4 months; The more serious the facial wrinkles, the shorter the duration.

There is no mention of Dysport.

2009

Ronald Moy Research

Ronald Moy's research focuses on adverse reactions. The selected sample is the patient who has repeatedly treated the eyebrow wrinkles for more than 5 times, and the injection interval is not less than 85 days (note that this study has requirements for the injection interval, which is originally about the reliability and tolerance of Dysport). The conclusion of this study is that in the treatment cycle of more than 13 months, the adverse reactions of repeated injection of Reloxin (Dysport) are reduced, and the treatment effect is good.

This research didn't mention Botox.

It seems unnecessary to compare these two studies, which means that the conclusions of the study are completely different from those of the placebo, but they were taken out for comparison and put the two pictures together, which led us to mistake the conclusions of the same study. I really want to praise the author after reading the book. It's really hard for you to collect and piece together such documents! But you forget that deep obsessive-compulsive disorder reminds you that compared with the contrast chart of recurrence time on the right, you have not marked it, and our doctors cannot verify it, so they can't understand where~

So when it comes to the maintenance time, what about the research of comparing the maintenance time of Botox and Dysport? Xiao Bian gives you the right way to open it. Xiao won't recommend any brand. After all, which brand is good, we can't say, and which brand is used by patients to inject slimming face, isn't it up to the patients? Oh, yes, and the right to make the final decision (actually, it's a purse). I just want to sort out the previous literature and research conclusions for all doctors. It is hoped that all doctors can deeply understand the clinical characteristics of each brand of injection face slimming, try to play a good role in every patient, and make good use of each brand of injection face slimming.

How long does Dysport last?

In China, the starting time and maintenance time of face thinning injection are particularly important, and these two indicators will greatly affect patient satisfaction.

Let's take a look at Dysport's previous research on duration. Here, we do not involve the comparison with other brands of injection slimming face, but simply look at the maintenance time of Dysport. What needs to be clear is that, within a certain dose range, the maintenance time of injection face thinning is related to muscle strength, muscle volume, injection face thinning dose, doctor injection technology and other factors.

According to the principle of face slimming injection, the maintenance time of all type A injection face slimming is about 90 days. That is to say, within 90 days after the injection of thin face, the light chain of thin face molecule injected by the injection of thin face core continuously splits the Snare25 protein. After 90 days, muscle strength began to recover gradually.

Mechanism of Dysport

In 2004, the small editor found an initial literature. Dr. Benjamin Ascher studied the maintenance time of the eyebrow ridges of three different doses of Dysport, and found that on the 90th day, 50 units of Dysport injection group (many studies converted 50U Dysport into 20U injection to thin face) 75. On the 180th day, 9% of the patients still existed, and 31% of the 50 units of Dysport had 31% of the patients.

Patient satisfaction was still as high as 93.1% in the 50U 180 day group.

Next, let's take a look at the contrast experiment of two brands of injection face slimming.

Comparative study on the maintenance time of Dysport and Botox

The half face study of Mark S Nestor in 2011

In 2011, Mark S Nestor compared Dysport and Botox in a randomized, double-blind, half face study. The author recruited 20 patients with severe forehead wrinkles in terms of maintenance time, starting time, etc., and injected a dose of 25 U of Dysport into the random side of the forehead, and 10 U into the other side of the forehead.

The research results of some patients showed that when the dose ratio was 2:5:1.0, Dysport's use time was significantly longer than injection of thin face. FMS (Frontal Movement Measurement Standard) evaluation, the median duration of Dysport treatment group was 105 days, and the injection of thin face group was 99 days, p=0.02。

The FRS (forehead rating scale) score showed that the median duration of Dysport was 160 days, and the thin face injection was 145 days. p>0.05， No statistical significance.

Some patient studies show that. FMS (Frontal Movement Measurement Standard) evaluation, the median duration of Dysport treatment group was 103 days, and the injection of thin face group was 87 days, p<0.04。

The FRS (Forehead Rating Scale) score showed that the median duration of Dysport was 119 days, and that of the injection group was 77 days, p=0.005。

Some patient studies show that. FMS (Frontal Movement Measurement Standard) evaluation, the median duration of Dysport treatment group was 72 days, and the injection of thin face group was 56 days, p=0.01。

The FRS (Forehead Rating Scale) score showed that the median duration of Dysport was 63 days, and that of the thin face injection group was 44 days, p=0.006。

So how are these results reflected in patients? Next, let's take a look at a real patient.

Similarly, we can clearly see that after a single injection of Dysport and Botox, the speed of wrinkles reappearing on the injection side of Dysport should be slower than that on the injection side of Botox.

Half face study of Ramtin Kassir in 2013

The research results show that among the patients injected in these two parts, Dysport lasted for a long time three months later, including 83% of the patients injected with Dysport still had wrinkles treatment in the fourth month, and 48% of the patients still had wrinkles injection and face thinning treatment in the fourth month.

Among them, 65% of patients with crow's feet prints injected Dysport still had crow's feet prints in the fourth month, and 47% of patients with crow's feet prints still had crow's feet prints in the fourth month.

Figure: Fishtail injection method (three points)

The research conclusion shows that there is no significant difference in the duration and starting time of improvement when injecting thin face and Dysport crow's feet in static state (P>0.05). Dynamic wrinkles, Dysport starts faster and lasts longer. Compared with the baseline severity, these two products can significantly improve the severity of wrinkles in static and dynamic situations. Dysport is more satisfied.

In fact, the minor editor has also searched a lot about Dysport's science writing habits based on limited space and minor editor (it is easy to write very long carelessly). Today, we will talk about Dysport, which is the science knowledge of maintaining time. If you think it is not enough, Xiao Bian would like to explain some literature about the maintenance time of different brands of injection face thinning.

Dysport's clinical features are far more than the quick start and long maintenance we mentioned earlier. There are many clinical features waiting for us to explore. For a newly launched brand, we should maintain a learning attitude. Xiao Bian once said that doctors' injection technology is more important than injection of face slimming products. After all, doctors are an important core to achieve slimming injections. I sincerely hope that doctors and fans of this platform can objectively face the articles that guide consumers to choose injection thin face brand and firmly learn injection technology.

The awe of medicine lies in seeking truth and truth. Only with awe and self-discipline can we feel secure and stable - encourage ourselves and give to those in need.