Risk of elder male children with birth defects
Male elder children with birth defects refer to the risks that men face when they give birth to children at a later age, which may lead to abnormal embryonic development or birth defects. Although the impact of women's age on fertility risk has been widely studied, the impact of older men's childbearing is also increasingly concerned. The following will elaborate on the risk of male elder children with birth defects from the aspects of genetic risk, sperm quality, reproductive system health and father's health.
1. Genetic risk
Older male fertility is associated with the risk of genetic mutations. With the growth of age, more mutations may accumulate in the sperm produced by men, which may lead to an increase in the number of genetic mutations in children. Research shows that the risk of chromosomal abnormalities in children born to men over 50 years old is 2-5 times higher than that of men over 20 years old. This chromosomal abnormality includes congenital diseases such as Down syndrome.
In addition, older men may also increase the probability of their children suffering from other genetic diseases, such as autism and schizophrenia. The study found that the increase in father's age was associated with the risk of these diseases. Therefore, men also need to consider the impact of genetic risk when deciding the time of childbearing.
2. Sperm quality
Another risk of male fertility at an advanced age is the decline in sperm quality. With the growth of age, the quality of sperm in men may decrease, leading to decreased fertility. Research shows that men over 40 years old have a higher probability of abnormal sperm morphology and declining sperm vitality than men over 20 years old. This may increase the risk of fertility disorders and malformations.
In addition to the decline of sperm morphology and vitality, the elderly male fertility is also related to the increase of DNA damage. The study found that the DNA damage in male sperm will increase with age, which may lead to genetic problems and abnormal birth of children.
3. Reproductive system health
The risk of elder male children with birth defects is also related to the health status of the reproductive system. With the growth of age, men may suffer from semen quality decline, sexual desire decline, erectile dysfunction and other problems. These problems may have a negative impact on fertility and increase the risk of deformed children.
In addition, the elderly male fertility may also lead to the decline of testicular function, thus affecting the hormone level produced by the testis. These hormone abnormalities may have adverse effects on sperm quality and embryonic development, and thus increase the incidence of malformations.
4. Father is healthy
The risk of male elder children with birth defects is also related to the father's own physical health. Chronic diseases such as long-term bad living habits, lack of exercise, hypertension and diabetes may lead to fertility problems and fetal abnormalities. Therefore, men should maintain good health before giving birth at an advanced age to reduce the risk of deformed children.
Summary
The risk of male elder children with birth defects mainly includes genetic risk, sperm quality decline, reproductive system health and father's own health. With the growth of age, men may have more genetic mutations and DNA damage, leading to genetic problems and increased risk of deformed children. At the same time, male sperm quality may decline, reproductive system health may be affected, and chronic diseases may also have a negative impact on fertility and fetal health. Therefore, when considering the birth time, men need to fully understand these risks and choose the appropriate birth time.
