Factors of difficult implantation of IVF
Difficulty in IVF implantation refers to the situation that the fertilized egg cannot be successfully implanted in the uterus in assisted reproductive technology. There are many reasons for IVF implantation difficulties, including abnormal hormone levels, abnormal uterine morphology, and blood circulation disorders. The following will elaborate on the factors of difficult IVF implantation from four aspects: abnormal hormone levels, abnormal uterine morphology, blood circulation disorders and other factors.
Abnormal hormone level
Abnormal hormone level is an important factor for difficult implantation. Hormones play an important role in regulating the implantation process. If some hormones are abnormal, it will affect the implantation of fertilized eggs. For example, progesterone is an important hormone to maintain early pregnancy. If the progesterone level is low, the embryo cannot be implanted in the uterus. In addition, the imbalance of the ratio of estrogen and progesterone will also increase the difficulty of IVF implantation.
Different hormone abnormalities lead to different implantation difficulties. Therefore, the hospital will conduct a comprehensive hormone test before IVF to understand whether the hormone level is normal. If it is abnormal, it will adjust the hormone balance through reasonable hormone replacement therapy.
Abnormal uterine morphology
Abnormal uterine morphology is another major factor in difficult implantation. Abnormal uterine morphology includes endometriosis, uterine septum and uterine fibroids. Endometriosis is the growth of endometrium outside the uterus, which will affect the implantation of embryos in the uterus. The uterine septum is the separation of the endometrium, forming two small chambers, so that the embryo cannot be implanted in the proper position. Uterine myoma is a common uterine tumor, which not only affects the implantation of embryos in the uterus, but also has adverse effects on embryonic development.
For abnormal uterine morphology, the hospital will try to improve the uterine morphology through surgery and other methods to improve the success rate of IVF implantation.
Blood circulation disorder
The disturbance of blood circulation is also one of the factors that lead to the difficulty of IVF implantation. Good uterine blood circulation is essential for embryo implantation, and some factors such as endometrial shedding, endometrial blood flow insufficiency will cause blood circulation disorders, which will affect embryo implantation.
Hospitals usually assess the blood circulation of the uterus by detecting hemodynamic parameters such as blood flow velocity and blood flow, and take relevant interventions, such as blood transfusion, vasodilators, to improve the success rate of embryo implantation.
Other factors
In addition to the above main factors, the difficulty of IVF implantation may also be related to other factors. For example, immune factors and chromosomal abnormalities may affect embryo implantation. Immune factors, including autoimmune diseases and positive antinuclear antibodies, will make the intrauterine environment unfavorable for embryo implantation. Chromosome abnormalities will affect the normal development and implantation of embryos.
For other factors, the hospital will carry out individual detection and intervention according to the specific situation to improve the success rate of IVF implantation.
Summary
The factors of IVF implantation difficulty mainly include abnormal hormone levels, abnormal uterine morphology, blood circulation disorders and other factors. Abnormal hormone levels will affect the implantation of fertilized eggs, abnormal uterine morphology will hinder the implantation of embryos in the uterus, blood circulation disorders will affect the blood supply of embryos, and other factors such as immune factors and chromosomal abnormalities will also affect the implantation. The hospital will conduct comprehensive testing and individualized intervention according to different factors to improve the success rate of IVF implantation.
