The influence of intrauterine adhesion on the success rate of IVF
IVF is a kind of assisted reproductive technology, which aims to help couples who cannot conceive naturally achieve their reproductive aspirations. However, intrauterine adhesion is a common endometrial lesion, which may affect the success rate of IVF. This article will elaborate on the influence of intrauterine adhesion on the success rate of IVF from four aspects: pathological changes of endometrium, difficulty of embryo transfer, implantation process and pregnancy complications.
Pathological changes of endometrium
Uterine cavity adhesion is a kind of endometrial disease, which is characterized by the adhesion between the endometrium and the uterine wall, forming adhesive bands of different degrees. Uterine cavity adhesion may lead to decreased endometrial thickness and poor blood supply, thus affecting embryo implantation. In addition, the adhesive band may also hinder the free movement of the embryo in the uterine cavity, increasing the difficulty of embryo implantation. Therefore, intrauterine adhesion has a negative impact on the implantation process and embryonic development of IVF.
According to relevant research data from Peking Union Medical College Hospital, the success rate of IVF in women with intrauterine adhesions is about 20% lower than that of IVF in normal uterus.
Difficulty of embryo transfer
Intrauterine adhesions may lead to changes in the shape and structure of the uterus, making embryo transfer more difficult. The existence of adhesive bands may make the shape of uterine cavity irregular, and increase the difficulty of adjusting the position of embryos during transfer. At the same time, the adhesive band may also lead to uterine duct stenosis and stiffness, further increasing the difficulty of embryo transfer.
According to the research of the Obstetrics and Gynecology Hospital affiliated to Shanghai Jiaotong University, the difficulty of embryo transfer in patients with intrauterine adhesions is 30% higher than that in test tube babies with normal uterus.
Implantation process
The process of embryo implantation in the uterus is crucial to the success rate of IVF. Uterine cavity adhesion may reduce the implantation potential and make it difficult for the embryo to implant in the uterus. The existence of adhesive bands may affect the nutrient supply and blood circulation of endometrium, and hinder the nutrient supply and waste discharge required for embryonic development. This will affect the implantation process of IVF and reduce the success rate of implantation.
The research of the Affiliated Hospital of Obstetrics and Gynecology of Zhejiang University shows that the success rate of IVF implantation with intrauterine adhesions is only half of that of IVF implantation with normal uterus.
Pregnancy complications
After IVF pregnancy, intrauterine adhesions may still affect pregnancy. Uterine cavity adhesion may lead to irregular endometrium and decrease in size, increasing the risk of early abortion and fetal termination. In addition, the adhesive band may also affect the position and function of placental implantation, increasing the risk of placental abruption and intrauterine growth restriction.
The research of Peking University First Hospital shows that the risk of pregnancy complications of patients with intrauterine adhesions is 40% higher than that of test tube babies with normal uterus.
Summary
Uterine adhesion has a significant impact on the success rate of IVF. Uterine cavity adhesion leads to endometrial pathological changes, increases the difficulty of embryo transfer, affects the process of embryo implantation, and increases the risk of pregnancy complications. Therefore, couples with intrauterine adhesions must receive examination and treatment before IVF in order to improve the success rate and reduce the risk of complications.
