Selection criteria for successful embryos of IVF at Shenzhen Peking University
IVF is a method of embedding the fertilized egg into the mother's uterus to achieve pregnancy through assisted reproductive technology. In Shenzhen Peking University Hospital, they attach great importance to successful embryo selection and use a series of standards to screen embryos to improve the success rate of IVF. This article will elaborate from four aspects: embryo quality, chromosome abnormalities, hereditary diseases and other factors.
Embryo quality
The quality of embryos should be considered first in the selection of embryos by Shenzhen Peking University Hospital. Embryo quality refers to whether the development, cell division and morphological structure of the embryo are normal. Doctors will evaluate the embryo development, nuclear division and cell morphology, and select an embryo that is well developed and has a high probability of successful implantation.
In embryo quality assessment, doctors usually pay attention to the number and population of cells, cell division rate and symmetry of the embryo. Normal embryos should have a certain degree of embryo development, the number of cells should be increased, and the division rate should be moderate and symmetrical. The hospital will select high-quality embryos for transplantation by observing the development of embryos in culture dishes and evaluating standards.
In addition, the hospital will evaluate the quality of the embryo according to its appearance and shape. Normal embryos should have regular cell structure and few fragments, and the shape should be regular, without obvious abnormalities and malformations.
Chromosomal abnormality
Chromosome abnormality is one of the main causes of abnormal embryonic development. In the process of embryo selection, Shenzhen Peking University Hospital screened embryos with chromosomal abnormalities by carrying out embryonic chromosome testing, thereby reducing the abortion rate and the risk of congenital malformations caused by chromosomal abnormalities.
Chromosome detection mainly includes routine karyotype analysis and paternity test. Through routine chromosome karyotype analysis, doctors can detect whether there are chromosome number abnormalities, structural abnormalities and other problems in the embryo. Paternity testing can be used to screen out genetic diseases and gene mutations.
Through chromosome abnormality screening, doctors can exclude embryos with chromosome problems, and improve the success rate and the birth rate of healthy infants.
Hereditary disease
Hereditary disease is also an important consideration in embryo selection. Shenzhen Peking University Hospital will test embryos through genetic disease gene screening to avoid passing on genetic diseases to the next generation.
Genetic disease gene screening mainly uses gene sequencing technology to detect whether there is a risk of carrying genetic disease genes. Doctors can judge whether embryos are at risk of carrying genetic disease genes according to family history, genetic counseling and gene sequencing results.
Through genetic disease gene screening, doctors can select embryos without genetic disease genes for transplantation to improve the birth rate of healthy infants.
Other factors
In addition to embryo quality, chromosome abnormalities and hereditary diseases, Shenzhen Peking University Hospital will also consider other factors for embryo selection. For example, female age, egg quality, past pregnancy history, reproductive system diseases, etc.
Female age is an important factor, because the growth of female age will reduce the quality and quantity of eggs and increase the risk of chromosomal abnormalities and genetic diseases. Doctors usually recommend more rigorous embryo selection for older women.
In addition, women's past pregnancy history and reproductive system diseases will also affect embryo selection. Doctors will consider whether women have ever had a history of poor pregnancy or reproductive system diseases, so as to develop appropriate embryo selection strategies.
Summary
In the successful embryo selection of IVF, Shenzhen Peking University Hospital adopted a series of criteria to screen embryos. These criteria include embryo quality, chromosome abnormalities, genetic diseases and other factors. Through the screening of these standards, hospitals can select embryos with good embryo quality, normal chromosomes and healthy genes for transplantation, and improve the success rate of IVF and the birth rate of healthy infants.
