Causes of slow doubling of HCG in test tube infants
IVF is an assisted reproductive technology, which combines eggs and sperm through in vitro fertilization, and transfers the fertilized eggs into the female uterus to help infertile couples achieve their reproductive aspirations. In IVF procedure, HCG (Human Chorionic Gonadotropin) test is usually performed to ensure the implantation of fertilized eggs and the normal development of embryos. However, sometimes the HCG value doubles slowly, which may be related to many factors. The following are possible reasons for slow HCG doubling in IVF:
1. Embryo development problems
The HCG value of IVF usually starts to rise within a few days after fertilization and should be doubled every 48 hours. If the HCG value doubles slowly, it may be due to embryonic development problems. Factors such as poor embryonic development, chromosome abnormalities or poor embryo implantation quality may slow down the doubling rate of HCG value.
At the same time, some women may also have ovarian dysfunction, leading to abnormal ovulation or poor egg quality, which will also affect the speed of HCG value doubling.
In addition, in the IVF program, multiple embryos may be selected for transfer, and some of them may be poorly developed, resulting in slow doubling of HCG values.
2. Problems of uterine environment
After the successful implantation of the fertilized egg, the internal environment of the uterus plays a vital role in the development of the embryo. Factors such as the thickness of endometrium, blood supply and the activity of immune system may affect the doubling speed of HCG value.
Some women may have endometrial abnormalities, such as adenomyosis, polyps, endometriosis, etc. These problems may lead to inadequate follicle support, thus affecting the normal development of embryos and the speed of doubling HCG values.
In addition, abnormal immune system may also lead to abnormal immune response of endometrium, which will affect embryo implantation and development, resulting in slow doubling of HCG value.
3. Hormone level
Hormone drugs used in IVF may affect the doubling speed of HCG value. The imbalance of hormone level may lead to the obstruction of embryonic development, and then affect the normal rise of HCG value.
In addition, some women may have abnormal hormone levels, such as ovarian insufficiency, polycystic ovary syndrome, etc., which will also have a negative impact on the speed of HCG value doubling.
The use method and dosage of drugs may also affect the doubling speed of HCG value. Therefore, it is essential to reasonably adjust the use scheme of hormone drugs to ensure the normal doubling of HCG value.
4. Internal environment problems
In addition to the influence of endometrium and hormone level, other environmental factors in the body may also affect the doubling speed of HCG value.
Some chronic diseases, such as diabetes and hyperthyroidism, may affect embryonic development and the normal increase of HCG value.
In addition, some drugs or living habits, such as smoking and drinking, will also have a negative impact on embryonic development and HCG value.
Summary:
The slow doubling of HCG in IVF may be related to the problems of embryonic development, uterine environment, hormone levels and other environmental problems in the body. These factors may affect the doubling speed of HCG value individually or simultaneously. In order to improve the success rate of IVF, doctors need to carefully check and evaluate the patient's physical condition, adjust the corresponding treatment plan, and provide personalized assisted reproductive technology services.
