What is the correlation between IVF NT and genetic diseases?
summary:
Test tube baby (IVF) is an assisted reproductive technology, which is often used for couples who cannot conceive naturally. One of the important steps is to screen the fetal sex and abnormal genes before embryo implantation, in which NT (thickness of fetal cervical zona pellucida) is a common method. This article will discuss the correlation between test tube infant NT and genetic diseases from the perspective of genetic diseases.
NT detection and common genetic diseases
1. Screening for chromosomal abnormalities:
NT test can evaluate whether the fetus has chromosome abnormalities. For example, trisomy syndrome (Down syndrome) is a common chromosomal disorder, which is related to the thickening of the zona pellucida in the neck of the fetus. NT test can be used to diagnose whether the fetus has chromosome abnormalities as soon as possible and save unnecessary pain that may occur.
2. Screening of genetic diseases:
NT testing can also assess whether the fetus carries the risk of specific genetic diseases. For example, cystic fibrosis is a common genetic disease, which will damage the respiratory system, digestive system and other organs of patients. NT testing can detect mutations in cystic fibrosis related genes and help couples understand whether their embryos are at risk of the disease.
3. Risk assessment of genetic predisposition:
NT testing can also assess whether the fetus is at risk for other common genetic diseases. For example, some genetic predisposition diseases such as hereditary heart disease and nervous system disease may be preliminarily screened through the relevant indicators of NT, which can remind parents to carry out further inspection for accurate diagnosis and intervention.
Accuracy and limitation of NT detection
1. Accuracy:
NT test has high accuracy in screening common genetic diseases. After a lot of clinical practice, it has been proved that NT detection can accurately detect chromosomal abnormalities and the risk of some genetic diseases.
2. Limitations:
Although NT detection has certain accuracy, there are still limitations. First of all, NT testing can only provide screening results for some genetic diseases, and risk assessment for other genetic diseases is limited. Secondly, NT testing also has a certain rate of misdiagnosis and missed diagnosis, which may lead to some normal embryos being misjudged as risky, or some risky embryos being missed.
Due to the above limitations, NT testing is only used as an auxiliary means to provide preliminary screening information, and finally needs to be combined with other genetic and clinical examination means to carry out accurate diagnosis and evaluation.
Combined with the practical application of hospital cases
Take Peking Union Medical College Hospital as an example. The hospital has an assisted reproduction center that provides IVF technology and related testing services. In NT testing, the hospital used neck ultrasound, serological indicators and other methods to comprehensively assess the risk of fetuses. In one study, the test tube infant NT detection accuracy rate of Peking Union Medical College Hospital reached more than 95%, providing reliable screening results for couples.
However, it should be noted that NT testing is only a part of the IVF process. When choosing hospitals and doctors, couples should take into account the professional level of the hospital, technical equipment, experience and professional background of doctors and other factors to ensure that high-quality testing results and consulting services are obtained.
summary
Test tube infant NT detection is closely related to genetic diseases. It can help couples assess whether the fetus is at risk of chromosomal abnormalities and specific genetic diseases, and provide relevant interventions. However, NT detection also has its accuracy and limitations, which need to be combined with other genetic and clinical examination methods for comprehensive judgment. When selecting hospitals and doctors, various factors should be comprehensively considered to ensure accurate and reliable screening results and consultation services.
