Effect of estrogen in test tube infant on ovary
IVF is a kind of assisted reproductive technology that transfers the fertilized egg into the female uterus for pregnancy through in vitro fertilization. During IVF, estrogen plays an important role in promoting follicular development and controlling ovulation. This article will elaborate the influence of IVF estrogen on ovary from four aspects: promoting follicular development, regulating luteal function, affecting endometrium and coordinating hormone balance.
Promote follicular development
In IVF technology, estrogen plays an important role by promoting the development of follicles. In the application of ovulation promoting agents, human chorionic gonadotropin (hCG) is often used to replace luteinizing hormone to simulate the natural ovulation process of women. HCG has a structure similar to luteinizing hormone, which stimulates follicular development and releases mature eggs by binding to ovarian receptors. Estrogen can interact with hCG in this process to promote follicle maturation and ovulation.
In addition, estrogen can also affect the development of follicles by regulating the secretion of follicle stimulating hormone (FSH). FSH is an important hormone regulating the development of follicles, and estrogen can enhance the responsiveness of follicles to FSH and promote the maturation of follicles. Therefore, estrogen administration during IVF can play a role in promoting follicular development.
Regulate luteal function
The corpus luteum is a temporary gland formed in the ovary after ovulation, which produces lutein and maintains the normal development of pregnancy. During IVF, estrogen can regulate the function of corpus luteum. The corpus luteum produces a large amount of lutein in the early pregnancy. This hormone plays an important role in the early pregnancy and embryo development. The application of estrogen can increase the secretion of lutein, thus promoting the smooth progress of pregnancy.
In addition, estrogen can also regulate the function of the late luteal phase. In the process of IVF, the application of estrogen can prolong the survival time of corpus luteum and increase the secretion of lutein, thus improving embryo implantation and survival rate. This is critical to the success rate of IVF.
Impact on endometrium
Before IVF, women need to prepare endometrium, that is, regulate the growth of endometrium by using estrogen. Endometrium is an important environment for embryo development. Only with appropriate thickness and good blood supply can good implantation conditions be provided.
Estrogen can promote the proliferation and secretion of endometrium, so that it has appropriate thickness and rich nutrition supply. In this way, the fertilized egg is easier to be implanted after being transplanted into the uterus, which is conducive to the smooth development of the embryo. Therefore, the application of estrogen in IVF is very important for endometrial preparation and embryo implantation.
Coordinate hormone balance
In the process of IVF, hormone balance is crucial for the regulation of ovarian function. Estrogen plays an important role in regulating hormone balance.
Estrogen can inhibit the expression of FSH receptor in early ovary, reduce the sensitivity of FSH receptor, thus inhibiting the development of early follicles and avoiding premature ovulation. At the same time, estrogen can also prevent the early occurrence of luteal phase by inhibiting the formation of corpus luteum, thus ensuring the success of IVF.
summary
Estrogen in IVF plays an important role in promoting follicular development, regulating luteal function, affecting endometrium and coordinating hormone balance. It participates in regulating the function of the reproductive system through multiple ways, providing support for the success of IVF. Therefore, in IVF technology, the rational use of estrogen is essential.
