Factors influencing the success of frozen embryo transfer in vitro
IVF frozen embryo transfer is an assisted reproductive technology, which can increase the success rate by cryopreservation of pregnant embryos, thawing and transplanting them into the mother at the required time. However, the success of frozen embryo transfer is affected by many factors. This article will elaborate from four aspects: embryo quality, endometrial preparation, patient age and hospital technical level.
Embryonic quality
Embryo quality is one of the keys to the success of frozen embryo transfer. Embryo quality mainly includes embryo age and embryo quality. The embryo age is the number of days when it leaves the ovary, which is usually frozen 3 to 5 days after fertilization. Higher quality embryos usually have higher ability of cell division and implantation. In addition, high-quality embryos have tight cell arrangement and appropriate embryo growth rate. The factors that affect the quality of embryos include patient factors and laboratory techniques.
First, the patient's age is an important factor. Young women produce better eggs, so their embryos are more likely to have better quality. Secondly, the technical level of laboratory operation also has a direct impact on embryo quality. High quality laboratories should have modern equipment, control appropriate temperature and humidity, and be operated by experienced technicians.
Endometrial preparation
Endometrial preparation is another key step in IVF frozen embryo transfer. The endometrium should have appropriate thickness and shape to facilitate embryo implantation and implantation. Endometrial preparation requires hormone therapy.
In general, the appropriate endometrial thickness should be between 8 and 14 mm, which usually requires appropriate estrogen replacement therapy. In addition, the timing of endometrial preparation is also very important. Usually, after the endometrium reaches the appropriate thickness, the endometrium is in the best state through artificial cycle control, which is conducive to the successful implantation and development of embryos.
Patient's age
The age of the patient is an important factor for the success of frozen embryo transfer. Generally speaking, young women have higher ovarian reserve and better egg quality, so their success rate of frozen embryo transfer is usually higher. However, with the growth of age, the ovarian function and egg quality of women will gradually decline, leading to a decline in the success rate of frozen embryo transfer.
In addition, age is associated with the risk of poor pregnancy outcomes. Some studies have found that patients over 35 years old are more likely to suffer from complications such as pregnancy induced hypertension syndrome, placental dysfunction and premature delivery during frozen embryo transfer.
Hospital technical level
The technical level of the hospital is also one of the important factors for the success of IVF frozen embryo transfer. A first-class hospital should have advanced laboratory equipment, a professional team of doctors and rich clinical experience.
The first-class hospitals can provide the latest assisted reproductive technology and standardized operating procedures to ensure the quality of embryos and the safety of pregnant women. In addition, the technical level of the hospital is also reflected in the comprehensive evaluation of patients' conditions and the formulation of individualized treatment plans.
summary
The factors influencing the success of IVF frozen embryo transfer include embryo quality, endometrial preparation, patient age and hospital technical level. High quality embryos and appropriate endometrial preparation are the key to ensure the success of transplantation. At the same time, young patients and hospitals with high technical level can also help to improve the success rate of frozen embryo transfer. To sum up, the success rate of IVF frozen embryo transfer can be improved by comprehensively considering these factors and selecting the appropriate treatment scheme at the appropriate time.
